At New York Blood Center, one of the most comprehensive blood centers in the world, our focus is on cultivating excellence by merging cutting-edge innovation with diligent customer service, groundbreaking research, and comprehensive program and service development. Join us as we work towards meeting and exceeding the growing needs of our diverse communities, further our lifesaving strategic goals in a rapidly changing environment, and expand our impact on the local, national, and global communities we serve.
The Lindsley F. Kimball Research Institute is a multi-disciplinary biomedical research institute with about 70 scientists in 16 independent laboratories (http://www.nybloodcenter.org/products-services/kimball-research-institute), and is conveniently located within 2 blocks of Rockefeller University, Weill Cornell Medical College, and the Memorial Sloan Kettering Institute. We are currently seeking candidates for a postdoctoral position in immunology and vaccinology.
The Research Fellow we seek will be involved in projects that center on the utilization of naturally secreted proteins of the filarial parasite Onchocerca volvulus as biologics for human use. Specifically, the focus will be on the O. volvulus protein Ov-ASP-1, which has intrinsic immunostimulatory properties and can be used as a powerful immunostimulatory adjuvant; it promotes a balanced Th1/Th2 antibody response and cellular responses to several soluble vaccine candidate antigens, and commercial inactivated viral vaccines, including trivalent-inactivated flu vaccines. Our long-term objective is to develop this highly effective and safe protein adjuvant for varied vaccines using a simple aqueous formulation and a much lower dose of antigen. By enhancing vaccine efficacy in this way, we can effectively increase the number of vaccine doses available that can be administered to humans to boost their immune response. This research has implications for the preventive treatment of various infectious diseases. Opportunity will also be available to study the mechanism of action of this adjuvant on its own, and in synergy with other adjuvants, as well as its putative intrinsic function during the parasite’s development in its human host. In addition, the Research Fellow could join other projects that focus on the pre-clinical development of effective vaccines against the filarial parasite, O. volvulus.
Applicants should have a PhD and/or MD with broad knowledge and experience in innate and adaptive immunity (human and mouse), system biology and vaccinology, with an interest in the translational aspects of these disciplines. Some experience in molecular techniques and bioinformatics is also required. Excellent analytical and communication skills, and a drive to independently ask and test scientific hypotheses are crucial. The appointed person will be expected to be productive, creative, and self-motivated, with a good track record in immunology and practical knowledge in cellular and molecular immunological techniques. You should also be able to work efficiently, and carefully organize experiments, as well as be able to work as a member of a team.