At New York Blood Center, one of the most comprehensive blood centers in the world, our focus is on cultivating excellence by merging cutting-edge innovation with diligent customer service, groundbreaking research, and comprehensive program and service development. Join us as we work towards meeting and exceeding the growing needs of our diverse communities, further our lifesaving strategic goals in a rapidly changing environment, and expand our impact on the local, national, and global communities we serve.
We are seeking candidates for a postdoctoral position (junior, senior, or a staff scientist position) in immunology and vaccinology.
The postdoctoral fellow will be involved in projects that center on the identification, characterization, and development of naturally secreted proteins of the filarial parasite Onchocerca volvulus as biologics (immunomodulatory and/or immunostimulatory proteins) for human use.
One aspect of the research is to continue studying the mechanism of action of the O. volvulus protein rOv-ASP-1, which has intrinsic immunostimulatory properties and was shown to be a powerful immunostimulatory innate adjuvant and promotes a balanced Th1/Th2 antibody response and cellular responses to several soluble bystander vaccine antigens and commercial inactivated viral vaccines, including the trivalent and quadrivalent seasonal influenza vaccines. One of the objectives of this study is to develop this highly effective and safe protein adjuvant for different vaccine formulations using a simple aqueous formulation and a much lower dose of the vaccine antigen. Another aspect of the project will be to test the hypothesis that combining rOv-ASP-1 with other innate cytoplasmic adjuvants will synergistically potentiate more effective and durable vaccine-induced protective immune responses against various pathogens specifically in aged populations, and hence restore some of the aging-associated deficits in critical regulatory pathways essential for effective antiviral responses. This research has implications for the preventive treatment of various infectious diseases.
The postdoctoral fellow could also join other projects in the lab that focus on the identification of filarial parasite-derived immune modulators that can suppress pro-inflammatory and autoimmune diseases.
PhD and/or MD
At least 3-5 years of post-doctoral experience and knowledge in innate and adaptive mechanisms of protective immunity (human and mouse), innate signaling pathways, systems immunology, vaccinology, with interest in the translational aspects of these disciplines. Extensive experience with flow cytometry and molecular techniques, and the use of experimental animal models is also required. Excellent analytical and communication skills as well as a drive to independently ask and test scientific hypotheses are crucial.
The appointed person is expected to be productive, creative, self-motivated with a good track record in the broader disciplines of innate and adaptive immunity with practical knowledge in cellular and molecular immunological techniques, able to work efficiently, carefully organize experiments and clearly communicate the research outcomes, as well as work well as a member of a team.
For applicants who will perform this position in New York City or Westchester County, the proposed annual salary is $73,760.00/year to $85,292/year. For applicants who will perform this position outside of New York City or Westchester County, salary will reflect local market rates and be commensurate with the applicant’s skills, job-related knowledge, and experience.
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